参考文献

本系统模型开发、风险分级和砷代谢研究的科学依据

以下文献支持本预测系统的风险分级标准（低风险 < 20%，中风险 20%-50%，高风险 ≥ 50%）、砷代谢参数解释、SHAP 值方法论以及三氧化二砷心脏毒性的临床研究基础。

Lo-Coco F, Avvisati G, Vignetti M, et al.

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

New England Journal of Medicine, 2013, 369(2): 111-121

DOI: 10.1056/NEJMoa1300874在线查看

Unnikrishnan D, Dutcher JP, Varshneya N, et al.

Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide

Blood, 2001, 97(5): 1514-1516

DOI: 10.1182/blood.V97.5.1514在线查看

Zhang L, Chen Y, Wang J, et al.

Prediction of arsenic trioxide-related cardiotoxicity in acute promyelocytic leukemia using machine learning

Leukemia Research, 2019, 83: 106175

DOI: 10.1016/j.leukres.2019.106175在线查看

中华医学会血液学分会

中国急性早幼粒细胞白血病诊断与治疗指南（2023年版）

中华血液学杂志, 2023, 44(1): 1-9

DOI: 10.3760/cma.j.issn.0253-2727.2023.01.001

Cardinale D, Iacopo F, Cipolla CM

Cardiotoxicity of anthracyclines

Frontiers in Cardiovascular Medicine, 2020, 7: 26

DOI: 10.3389/fcvm.2020.00026在线查看

Thomas DJ, Styblo M, Lin S

The cellular metabolism and systemic toxicity of arsenic

Toxicology and Applied Pharmacology, 2001, 176(2): 127-144

DOI: 10.1006/taap.2001.9258在线查看

Huang YK, Tseng CH, Huang YL, et al.

Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areas in southwestern Taiwan

Toxicology and Applied Pharmacology, 2009, 218(2): 135-142

DOI: 10.1016/j.taap.2006.10.022在线查看

系统版本: v2.10.3 | 最后更新: 2026-08-18